Caloric Restriction Mimetics in Aging, Improved Cancer Chemotherapy, Autophagy Anti-Obesity Effect

Parent Episode: Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Caloric restriction mimetics – compounds that “trick” cells into inducing autophagy even in the setting of sufficient nutrient levels – include resveratrol, which is found in red wine, and spermidine, which is found in cheese. These compounds work by inducing the same biochemical changes within cells that starvation and fasting induce, such as the acetylation and deacetylation of proteins. Emerging research suggests that caloric restriction mimetics, when used in conjunction with chemotherapy, enhance the anti-cancer immune response that makes chemotherapy have lasting effects. In this clip, Dr. Guido Kroemer describes the autophagy-inducing effects of calorie restriction mimetics such as spermidine and resveratrol.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $5 / month
  • Loyal Fan

    $10 / month
  • Super Fan

    $25 / month
  • Power Supporter

    $50 / month
  • Heroic Supporter

    $125 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.