Caloric Restriction Mimetics in Aging, Improved Cancer Chemotherapy, Autophagy Anti-Obesity Effect
Caloric restriction mimetics – compounds that “trick” cells into inducing autophagy even in the setting of sufficient nutrient levels – include resveratrol, which is found in red wine, and spermidine, which is found in cheese. These compounds work by inducing the same biochemical changes within cells that starvation and fasting induce, such as the acetylation and deacetylation of proteins. Emerging research suggests that caloric restriction mimetics, when used in conjunction with chemotherapy, enhance the anti-cancer immune response that makes chemotherapy have lasting effects. In this clip, Dr. Guido Kroemer describes the autophagy-inducing effects of calorie restriction mimetics such as spermidine and resveratrol.
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