Related Episodes for Are the benefits of exercise and fasting additive? | Dr. Mark Mattson

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“A recent meta-analysis also found small benefits in selected cognitive domains, including memory and processing speed, with responses that may depend on age, diet, baseline stores, stress, dose, and the cognitive test used.”

“A separate six-week randomized study in 30 healthy young adults found that neither 10 nor 20 grams per day improved the tested cognitive outcomes compared with placebo. The result is an important counterweight to the acute sleep-deprivation experiment.”

“Acute stress may create a different context. In a double-blind crossover study of 15 adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed brain high-energy phosphate measures and improved selected cognitive outcomes.”

Dan Pardi: Ph.D. candidate studying sleep neurobiology at Stanford and University of Leiden, co-founder of Dan’s Plan online wellness company.

“However, vegans and vegetarians frequently have higher levels of other micronutrients, such as vitamins C and E. Getting the required micronutrients is essential for maintaining optimal health when following a vegan diet.”

“Tools, companies, and resources mentioned OpenAI - AI research and deployment company behind widely used GPT systems and developer tools; its science case study describes GPT-5 helping Unutmaz's lab resolve a long-standing immunology question.”

“Dr. Rhonda Patrick discusses the differences between different forms of DHA in terms of bioavailability and transport into different cells. She talks about why a specific type of DHA (DHA in phosphatidylcholine) is more readily transported into the brain because it forms DHA-lysophsophatidylcholine.”

“Dr. Rhonda Patrick – who wears a continuous glucose monitor – has found that her post-smoothie blood glucose levels are markedly lower when her smoothie contains moringa powder. In this clip, Dr. Rhonda Patrick shares anecdotal evidence that moringa reduces blood glucose levels.”