Related Episodes for Bioenergetic superiority of ketones and their role in reducing oxidative stress | Dominic D'Agostino

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“Long-lived people eventually develop age-related diseases – just later in life, a phenomenon referred to as “compression of morbidity.” The onset of these diseases is influenced by a variety of factors, including genetics, environment, and lifestyle.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spread across 8.5 hours reduced post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In a UK Biobank study of 25,241 adults who reported no leisure-time exercise, about three daily bouts lasting one or two minutes were associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”

“A dose-response meta-analysis of 30 prospective studies, including more than 1.18 million participants, associated each additional daily cup with about a 6 percent lower incidence of type 2 diabetes, with similar patterns for caffeinated and decaf coffee.”

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”

“Severe sleep deprivation offers one such model. In a randomized crossover study of 15 healthy young adults, a single dose of 0.35 grams per kilogram changed brain-energy measures and reduced deterioration on selected cognitive tasks during about 21 hours awake.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“A single 0.35-gram-per-kilogram dose of creatine monohydrate, equal to 24.5 grams for a 70-kilogram adult, reduced fatigue and improved word memory and processing speed on selected tasks versus placebo. It also changed brain-energy measures.”

“She uses that result to make consistency practical. Aerobic exercise does not need to be all-out every day, but sessions that raise heart rate and improve cardiorespiratory fitness provide a meaningful brain stimulus.”