Related Episodes for Considerations for choosing sulforaphane / glucoraphanin supplements | Jed Fahey

“In this clip from Dr. Rhonda Patrick's appearance on Modern Wisdom, she explains how a large post-meal glucose rise and fall can contribute to the sluggish feeling people call brain fog. Food order offers one practical lever.”

“00:44:53 - How marine omega-3 fatty acids EPA and DHA may be one of the safest supplements to delay telomere attrition, with each 1-standard deviation increase in levels associated with a 32% reduction in the odds of telomere shortening and how one four-month double-blinded supplementation study showed that omega-3 could even lengthen telomeres.”

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“However, exercising while taking a non-steroidal anti-inflammatory agent (NSAID) may blunt the initial rush of acute inflammation and negate some of the long term health effects of exercise.”

“A large meta-analysis found that protein supplementation improved resistance-training gains in muscle size and strength, with little additional lean-mass benefit above an estimated total intake of about 1.6 grams per kilogram per day for most participants.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“1 2 3 00:31:57 - How skill-based exercise, such as yoga, Tai chi, boxing, tango or skateboarding may play a special role in ameliorating some of the effects of the disease by driving circuit-specific effects, by creating top-down cognitive challenge for skills involved in a patient's movement through space.”

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”