Related Episodes for Epigenetic Aging: How old is your DNA?

“Alterations in magnesium and oxidative status during chronic emotional stress - Young adults undergoing persistent or intermittent stress like anticipating military conflict) experienced substantial decreases in their overall and plasma magnesium concentrations over three months.”

“Rumination, the practice of dwelling on external stressors to excess, can set in motion a cascade of hormonal and physiological responses that harm mental and physical health. Meditation has been shown to reduce rumination and its negative effects, however, and influences the gene expression of as many as 500 genes, many of which are in the brain.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“Using a Mendelian randomization analysis, scientists determined that people carrying genetic variants associated with low vitamin D levels have higher mortality from respiratory tract infections and higher all-cause mortality.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“A pooled analysis of 17 prospective cohorts associated higher circulating long-chain omega-3 levels with lower total mortality, but it does not prove that raising an individual’s index causes added years of life or offsets smoking.”

“A meta-analysis of resistance-training trials found that protein supplementation produced modest additional gains in strength and fat-free mass, with average fat-free-mass benefit plateauing near 1.62 g/kg/day. This is a group estimate, not a precise requirement for every older adult.”

“In a small immobilization trial, five grams per day of omega-3 fatty acids reduced the loss of muscle volume in young women compared with sunflower oil, supporting continued research on omega-3s and disuse atrophy. Heat is the fourth proposed tool.”

“The question of whether NAD+ is derived directly from NR or NMN in certain tissues rather than being salvaged from nicotinamide may, in particular, have implications for whether or not oral administration may be hampered in achieving maximal NAD+ status due to the fact that the process of salvaging NAD+ from nicotinamide is subject to feedback inhibition.”

“A randomized-trial meta-analysis found a higher atrial-fibrillation risk with marine omega-3 supplementation, with a stronger signal at doses above 1 gram per day; the included populations generally had cardiovascular disease or elevated cardiovascular risk.”