Ranked by shared topics, with one result from each original episode.
“In this Aliquot, I walk through how that plays out in humans, where the strongest evidence shows up, and where it doesn't, with NAD researcher Dr. Charles Brenner—and why I'm taking it now after being skeptical.”
“Modulating autophagy – through fasting and exercise (which both increase acetyl CoA) or intake of nutrients like spermidine – represents a promising therapeutic approach for extending human lifespan and healthspan.”
“It has attracted interest for its potential to activate mitophagy, the process cells use to clear out damaged mitochondria. In this Aliquot, I explain why mitochondrial cleanup matters for aging, why urolithin A production varies, and what early human studies suggest about its potential benefits.”
“A more useful approach is to focus on what you can do to reduce its effects. In this Aliquot, Dr. Kelly Starrett explains why standing more is not enough, how to build movement into your workday, and why it matters for long-term mobility.”
“The timing of eating and exercise, especially in elite athletes, hasn't been studied and may, in fact, require self-experimentation by the athletes to identify the perfect interval of fasting to support their optimal performance.”
“But exercise — especially intense exercise — can also help to manage the symptoms once the disease develops. These Aliquot segments feature Dr. Giselle Petzinger, a board-certified neurologist who specializes in the care of patients with Parkinson's disease.”
“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”
“The decline of deep sleep begins early in life, nearly disappears by age 80, increasing the risk for Alzheimer's disease. These Aliquot segments feature Dr. Charles Raison, a professor of psychiatry, and Dr. Matthew Walker, a professor of neuroscience and psychology.”
“As a result, sauna use is associated with lower risk of cardiovascular and neurodegenerative diseases. The mechanisms that drive these effects are likely due to increased heat shock proteins and metabolic and hormonal changes that accompany exercise and sauna use.”
“Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. This Aliquot features Drs. Guido Kroemer, Dominic D'Agostino, Valter Longo, Peter Attia, and Rhonda Patrick.”