Related Episodes for Tim Ferriss’ personal ketosis biomarkers

“The oversimplified view that high-density lipoprotein (HDL) cholesterol is good, and low-density lipoprotein (LDL) cholesterol is bad has led to misunderstandings of the relationship between cholesterol and cardiovascular disease risk.”

“Preliminary findings from a study analyzing UK Biobank data with over 25,000 participants suggest that even 3-4 minutes of VILPA daily could reduce all-cause mortality risk by 25-30%.”

“Timing provides a practical compromise. Dr. van Loon favors protecting the first several hours after resistance or endurance training, then placing cold exposure later in the day or on a recovery day when muscle adaptation is the priority.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“If you have used a consumer genetic testing service like 23andMe or AncestryDNA and want to learn more about whether or not the data indicates your specific genotype on these SNPs, check out our free viral report here.”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“A recent meta-analysis also found small benefits in selected cognitive domains, including memory and processing speed, with responses that may depend on age, diet, baseline stores, stress, dose, and the cognitive test used.”

“Acute stress may create a different context. In a double-blind crossover study of 15 adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed brain high-energy phosphate measures and improved selected cognitive outcomes.”

Dan Pardi: Ph.D. candidate studying sleep neurobiology at Stanford and University of Leiden, co-founder of Dan’s Plan online wellness company.