Related Episodes for How the cell prioritizes and targets organelles and protein aggregates for degradation by autophagy

“A systematic review and meta-analysis found no evidence that one time of day produces universally better improvements in health or performance, although gains can be larger when the time of training matches the time of testing.”

“Uric acid adds another long-range signal. In the Swedish AMORIS cohort, 1,224 people who reached age 100 tended to have lower midlife glucose, creatinine, and uric acid than peers who did not become centenarians.”

“Since then, countless studies have tested Pauling's theories about vitamin C, colds, and cancer (and many others), and a substantial body of evidence has emerged, identifying critical roles for vitamin C in immune function, cardiovascular and respiratory health, cognitive development and preservation, and many other aspects of human health.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“Dr. Patrick also distinguishes general-population evidence from people with diabetes or insulin resistance, where some observational studies report different risk patterns and residual confounding remains substantial.”

“Imaging studies also associate higher visceral fat with increased cancer incidence in some populations, while large cohort analyses link greater waist circumference with higher all-cause mortality.”

“In a randomized trial of 120 older adults, a walking program that progressed to about 40 minutes three times per week increased anterior hippocampal volume by approximately 2 percent and improved spatial memory over one year.”