Related Episodes for Lactate and ketone metabolism in context of brain energetics and lactate shuttle | Peter Attia

“In this episode, Dr. Rhonda Patrick chats with Dr. Darya Rose and Kevin Rose. Kevin talks about his experiments with a ketogenic diet featuring large amounts of vegetables combined with fats to drive his ketosis and other ideas and projects he is working on.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“A larger randomized-trial meta-analysis also found modest average reductions in BMI, waist circumference, and body-fat percentage, although protocols and populations varied. These averages do not mean that HIIT alone guarantees fat loss.”

“The physical activity guidelines and estimates on how much activity we need are heavily based on self-reported activity, which is useful but imperfect: people remember going for a run, but they forget the short, intense bursts in daily life like sprinting up stairs, chasing kids, and running to catch a bus.”

“Wearable-device research in more than 25,000 adults who reported no structured exercise linked about three one- to two-minute vigorous bouts per day with substantially lower all-cause, cardiovascular, and cancer mortality.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In this clip from Dr. Rhonda Patrick's appearance on The Diary of a CEO, she explains that a shorter eating window can make calorie reduction easier, while a longer overnight fast shifts fuel use toward fatty acids and ketones.”

“Standard metabolic screening still relies on validated laboratory measures such as A1c, fasting plasma glucose, or a two-hour glucose value after a standardized oral glucose tolerance test. Skin changes or unexpected glucose patterns can therefore be useful prompts for a clinical evaluation.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”

The video serves as a companion to our 15-page Sprouting Guide (https://www.foundmyfitness.com/sprouting) + Q&A with Dr. Jed Fahey (https://www.foundmyfitness.com/episodes/jed-fahey-q-a) – an illustrated manual to the basics of sprouting that includes a brief summary of the science of sulforaphane plus insights from one of the top researchers in the field of chemoprotection.