Related Episodes for Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation

“Uric acid adds another long-range signal. In the Swedish AMORIS cohort, 1,224 people who reached age 100 tended to have lower midlife glucose, creatinine, and uric acid than peers who did not become centenarians.”

“During the peak phase, participants sometimes completed two interval sessions per week, while the longer maintenance phase generally used one interval session alongside continuous endurance work and strength training.”

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“Dr. Patrick also distinguishes general-population evidence from people with diabetes or insulin resistance, where some observational studies report different risk patterns and residual confounding remains substantial.”

“In this clip from Dr. Rhonda Patrick's presentation at the Vibrant Wellness Longevity Summit, she explains how the Omega-3 Index measures EPA and DHA in red-blood-cell membranes as a longer-term marker of omega-3 status.”

“In this clip from Q&A #68, Dr. Rhonda Patrick compares stearic, palmitic, myristic, and lauric acids and explains why chocolate, cheese, butter, and coconut oil can produce different lipid responses.”

“In a randomized trial of 120 older adults, a walking program that progressed to about 40 minutes three times per week increased anterior hippocampal volume by approximately 2 percent and improved spatial memory over one year.”