Related Episodes for How NAD+ resets the circadian clock and regulates sirtuins | David Sinclair

“Use of these substances is often carried out in a highly controlled cultural context for religious or healing purposes or for divination and not casual use. The use is often accompanied by strong mystical experiences that have great significance to the user.”

“Cognitive behavioral techniques help people who have insomnia identify what those changes are and develop strategies that promote sleep, such as practicing good sleep hygiene, stimulus control, and sleep restriction.”

“More importantly, however, these effects were sustained – even after several months – demonstrating that sulforaphane did not exhaust the body's capacity to protect itself from environmental threats and suggesting that regular consumption of sulforaphane in foods or dietary supplements provides a kind of nutritional "seatbelt" that protects against future toxic exposures.”

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Dr. Patrick also discusses glucose, HbA1c, fasting insulin, kidney and electrolyte markers, hs-CRP, fibrinogen, thyroid tests, CBC, vitamin D, sex hormones, IGF-1, and the Omega-3 Index.”

“I am simply saying you would be even more healthy if you also included fiber...if you also included fruits and vegetables.” - Layne Norton, Ph.D. The Carnivore Diet Eating an all meat or all animal product diet—commonly referred to as the carnivore diet—has been hailed by many as the only diet that’s provided a cure for their autoimmune disease or other health issues.”

“Morning light also works as part of a full day-night contrast. Dr. Huberman favors brighter days and dimmer, warmer evenings, because late bright light can delay sleep timing while earlier light supports a stronger daytime signal.”

“If your magnesium levels are inadequate, then your ability to boost mitochondrial number during HIT will be dampened, thus, compromising performance and the mitochondrial mass you would have otherwise gained as a consequence of your hard work and effort.”

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”