How NAD+ resets the circadian clock and regulates sirtuins | David Sinclair
Low energy levels, such as those that would occur during exercising, fasting, or caloric restriction, stress the cell. In turn, cellular levels of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy, rise, switching on energy-generating pathways and activating enzymes such as sirtuins. Levels of NAD+ vary according to nutrient intake, activity, and even time of day. In fact, the body's circadian rhythms are subject to NAD+ levels, which drive the body's master "clock." Altered NAD+ levels may be the root cause of jet lag and the overall loss of energy we experience as we age. Modulating NAD+ levels and the pathways in which it plays a role may be the key to extending healthspan and lifespan. In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.
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