Related Episodes for Roland Griffiths, Ph.D. on Psilocybin, Psychedelic Therapies & Mystical Experiences

“Early biomarkers of vascular dysfunction, such as soluble platelet-derived growth factor receptor-beta (sPDGFR-β), can help identify individuals at risk for developing Alzheimer's disease. These biomarkers are being validated on high-throughput platforms for large-scale testing.”

“Because of alcohol’s effect on other organs and the evidence that any dose of alcohol appears to elevate cancer risk, Dr. Huberman thinks that zero to two drinks per week represents a “safe zone” as long as you’re of age, not pregnant, and not an alcoholic.”

“Many harmful behaviors, such as overeating or smoking, are rooted in reward-based processes. Consequently, people often engage in these behaviors in response to triggers, such as emotional or mental stressors, or external prompts, such as advertising and social pressures.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“This is a proposed metabolic advantage, not proof of slower brain aging. Small TBI trials found that sodium lactate lowered intracranial pressure more than mannitol in severe TBI and improved cognitive scores more than 3% sodium chloride in mild TBI.”

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“APOE4 is the strongest common genetic risk factor for late-onset Alzheimer's disease, while physical activity, sleep, blood pressure, and diet remain important modifiable influences across the lifespan. Nutrition may offer additional support.”

“A growing body of evidence suggests that exogenous lactate or beta-hydroxybutyrate may be useful in the treatment of traumatic brain injury. These compounds allow glucose to be spared as an energy source and instead be utilized in the synthesis of the antioxidant glutathione, which is vital following a brain injury.”

“Prospective human cohorts have reported associations between prenatal BPA measurements and later child behavior, sometimes with sex-specific patterns, but results are inconsistent and residual confounding remains possible.”

“This takes on special relevance for omega-3 fatty acids, which play critical roles in brain development. Evidence suggests that omega-3 fatty acids in breast milk increase brain volumes in multiple regions of the brain and might influence intelligence, behavior, and communication.”