Related Episodes for The link between sirtuins, calorie restriction, fasting, and the insulin pathway | David Sinclair

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“A larger randomized-trial meta-analysis also found modest average reductions in BMI, waist circumference, and body-fat percentage, although protocols and populations varied. These averages do not mean that HIIT alone guarantees fat loss.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“While the alcohol concentration in breast milk is low, infants cannot metabolize it very well and can cause altered sleep habits, decreased appetite, weight gain, low blood sugars, and impaired motor development.”

“Use of these substances is often carried out in a highly controlled cultural context for religious or healing purposes or for divination and not casual use. The use is often accompanied by strong mystical experiences that have great significance to the user.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Dr. Patrick also discusses glucose, HbA1c, fasting insulin, kidney and electrolyte markers, hs-CRP, fibrinogen, thyroid tests, CBC, vitamin D, sex hormones, IGF-1, and the Omega-3 Index.”

“If we eat carbohydrate-containing foods when melatonin levels are high, our pancreas cannot produce the insulin needed to use the glucose. Therefore, eating too close to bedtime or immediately upon waking, before nightly melatonin levels have declined, may hamper the body's ability to process glucose.”

“I am simply saying you would be even more healthy if you also included fiber...if you also included fruits and vegetables.” - Layne Norton, Ph.D. The Carnivore Diet Eating an all meat or all animal product diet—commonly referred to as the carnivore diet—has been hailed by many as the only diet that’s provided a cure for their autoimmune disease or other health issues.”

“It remains unknown whether these levels are sufficient for optimal immunological functioning. A large meta-analysis of 32 studies, spanning nearly 50 years, suggests that 25-hydroxyvitamin D levels below 30 ng/mL are associated with a higher risk of death from all causes.”