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“Researchers recruited 1,031 participants from the large VITAL trial who took vitamin D3 (2,000 IU daily), omega-3 fatty acids (1 gram daily), both, or a placebo for four years. The researchers measured each person's telomere length at the start of the study, then again two and four years later.”

“To evaluate the influence of the omega-3 fatty acids versus placebo, the authors measured telomere length, telomerase activity, and markers of oxidative stress (known as F2-isoprostanes).”

“The authors went on to posit that the similarities between obesity and aging are driven by shared molecular- and cellular-level mechanisms, including increased levels of reactive oxygen species, mitochondrial dysfunction, cellular senescence, increased apoptosis, impaired autophagy, and increased inflammation.”

“Chronic sleep deprivation, a risk factor for cardiovascular and Alzheimer’s diseases, is common among adults in industrialized nations, with many reporting less than seven hours of sleep each night during the workweek.”

“The multivitamin also affected parts of the epigenetic clock GrimAge, with changes in DNA patterns linked to telomere length (the protective caps at the ends of chromosomes) as well as beta-2 microglobulin, cystatin C, and growth differentiation factor 15, which are markers associated with inflammation, kidney function, and mitochondrial dysfunction.”

“1 02:37:05 - Mothers that chew xylitol gum starting mid-pregnancy and continuing until 6-12 months after birth lowered the oral streptococcus mutan bacteria, which is an anaerobic bacteria that plays a significant role in tooth decay, in their toddlers/children.”

“A 2020 study found that hyperbaric oxygen therapy prevented telomere shortening and cellular senescence – hallmarks of cellular aging – in older adults, effectively reversing the aging process. The study involved 35 older adults who underwent 60 hyperbaric oxygen therapy treatments over three months.”

“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”

“Across the modeled dose-response curves, one vigorous minute corresponded to 4.1 moderate minutes for all-cause mortality, 7.8 for cardiovascular mortality, 5.4 for major cardiovascular events, 9.4 for incident type 2 diabetes, and 3.5 for cancer mortality.”

“Dr. Patrick also revises an earlier concern about acrylamide: although roasting can form it, the human evidence she reviews does not show that ordinary coffee intake raises cancer risk, and the overall epidemiology points in the opposite direction for several cancers.”