Search results for depression

“It has previously been shown that inflammatory molecules produced as a consequence of gut permeability can cross the blood-brain barrier and lead to anxiety and depression. Additionally, the vagal nerve connecting the gut to the brain may also be at play here.”

“Data from seven randomized controlled trials in people that were ill and depressed showed a significant antidepressant effect of anti-cytokine (anti-inflammatory) treatment compared with placebo. Further analysis showed that the antidepressant effect was not associated with improvement in primary physical illness.”

“A single session of whole-body hyperthermia (similar to the sauna) produced a significant antidepressant effect apparent within a week of treatment that persisted for 6 weeks after treatment in people with major depressive disorder.”

“A new study finds that the gut bacteria Bacteroides produces the neurotransmitter GABA and that people with major depression have fewer Bacteroides gut bacteria compared to healthy individuals.”

“Mounting evidence suggests that nutrition plays a huge role in depression by affecting levels of systemic inflammation. Inflammatory molecules and cytokines are able to have these sort of effects is because they are able to cross over the blood-brain-barrier and disrupt neurotransmitter production and release.”

“FTA: > The researchers found many regions that are "hyper-connected – or talking to each other a little too much – among those who have a history of depression," Jacobs said. These hyper-connected brain networks were related to rumination, with individuals thinking about a problem over and over without actively trying to come up with a solution.”

“From the article: > Serum BDNF levels were lower in bipolar disorder patients during both manic and depressive episodes, as compared with euthymic patients and healthy controls. This finding suggests that the effects of pharmacological treatment on BDNF levels may be associated with mood stabilization.”

“Compelling evidence suggests that the relationship between inflammation and depression is indeed causal – and LPS may play a role. In studies in which participants receive LPS injections, their circulating levels of proinflammatory cytokines, including interleukin (IL)-6 and tumor necrosis factor-alpha (which are downstream of toll-like receptor activation), increase markedly.”

“Dr. Candow and Dr. Patrick also review early work on mood, cognition, and neurological conditions. Existing depression studies have used creatine as an adjunct to standard treatment, while evidence in neurodegenerative disease remains limited.”

“Evidence suggests that microglia activation influences mood. The investigators used chemogenetics, a research technique that uses drugs or other chemicals to modulate neural activity, to stimulate microglia activation in the brains of mice.”