Aliquot #117: The Science of Lactate in Brain Performance
“In this Aliquot, Dr. George Brooks – who identified the lactate shuttle – Dr. Martin Gibala, and I discuss how lactate supports healthy brain function and enhances cognitive performance.”
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“In this Aliquot, Dr. George Brooks – who identified the lactate shuttle – Dr. Martin Gibala, and I discuss how lactate supports healthy brain function and enhances cognitive performance.”
“Eating a typical Western diet – high in processed foods and sugar-sweetened beverages – raises blood glucose and insulin levels, promotes inflammation, and contributes to many neurological disorders, including Alzheimer's disease.”
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“Vascular dysfunction is a common feature of most forms of dementia, including Alzheimer's disease. Identifying and treating vascular problems in the brain's smallest blood vessels could postpone the onset of symptoms and improve the quality of life for people with dementia.”
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“By studying ischemic wounds, which are analogous to an aged brain or clogged arteries, researchers observed increased blood flow when ketone levels were elevated. Nutritional ketosis may also reduce neural inflammation which may be a predictor of seizure in epilepsy.”
“Keeping our brains sharp throughout the lifespan is essential for optimal performance. Lifestyle behaviors such as exercise, dietary modification, and sauna use influence brain health.”
“Dr. Rhonda Patrick visits the Kevin Rose Show to discuss metformin, magnesium L-threonate, fish oil and brain health, sulforaphane, goitrogenic activity of isothiocyanates, sauna, and more. Subscribe to the Kevin Rose Show on iTunes. Learn more about Kevin Rose @kevinrose on Twitter. KevinRose.com. The Kevin Rose Show on iTunes. Foundation by True Ventures.”
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“The use of alternate fuel sources allows glucose to be spared for the metabolic pathways that require it. In this clip, Dr. Dominic D'Agostino discusses the metabolic flexibility of the brain to use various substrates, including ketones, for energy.”
Episode
“Finally, choline is also a precursor for phosphatidylcholine, the major component of all cell membranes, which affects the structure, permeability and function of cells and is particularly important in neurons since it plays a role in general neurotransmission.”
Q&A
Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Episode
“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”
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