Search results for genome

“Vitamin D receptor and gene regulation The active steroid hormone form of vitamin D regulates the expression of more than 900 genes in the body, roughly 5 percent of the human protein-encoding genome. It accomplishes this by binding to the vitamin D receptor in the cell.”

“The problem is that whole-genome sequencing showed that while CRISPR is effective in correcting a faulty gene of interest, it also introduced up to 1,500 other mutations in other parts of the genome. While CRISPR is still very promising...more work needs to be done to understand why this technique can introduce over a thousand mutations to the genome.”

“"A meta-analysis that used data on more than 800,000 people from three large genome-wide association studies of depression identified 269 genes, 102 independent variants, and 15 gene sets associated with depression.".”

“Google Genomics: a cloud computing service, connecting and comparing genomes by the thousands, and soon by the millions, is what’s going to propel medical discoveries for the next decade.”

“These clocks orchestrate the regulation of gene expression that coordinates metabolic programs needed to support bodily functions. Of the entire human genome, approximately 15 percent of the genes display daily oscillations, or fluctuations, in their activity.”

“Drinking two to three cups per day is linked to roughly a 60% reduced risk of developing diabetes, a statistic that highlights coffee's robust metabolic benefits that arise from its ability to activate AMP-activated protein kinase (AMPK), a critical regulator of cellular energy metabolism.”

“Researchers evaluated the effects of these changes in a study involving 37 men and women who practiced voluntary long-term caloric restriction (approximately 30 percent of habitual intake) for 3 to 15 years, compared to sedentary and fit people eating a traditional Western diet.”

“In an attempt to control for the healthy user bias (the possibility that people who take multivitamins may have better lifestyle habits than nonusers), the statistical analyses were adjusted for confounding factors like age, sex, education, alcohol and tobacco use, BMI, physical activity, diet quality, family history of cancer, and the use of other supplements.”

“Similarly, in a genome-wide association study, people carrying a variant of the FOXO3 gene tended to have a reduced inflammatory response (downregulation of TNFα and several other pro-inflammatory cytokines and upregulation of IL10, a cytokine associated with anti-inflammatory effects).”

“A new type of gene editing CRISPR system has been developed that can erase large pieces of DNA from a specific site in the human genome and has the potential to eliminate viruses like herpes simplex, Epstein-Barr, and hepatitis B.”