Search results for genetics

“- Peter Attia, M.D. People mentioned in this episode Helen Hobbs, MD – Researches how genetic differences cause lipid metabolism disorders. She discovered the link between a rare mutation in the PCSK9 gene and extremely low cholesterol levels, which led to the development of PCSK9 inhibitors, potent cholesterol-lowering drugs.”

“To try to figure out what's going on we discuss what the randomized controlled trials say, which are better at establishing causation, and also talk a lot about lipid biology... and genetics! This podcast also has relevance in helping to explain why some people do not do as well on a ketogenic diet.”

“Two mRNA vaccines (Pfizer-BioNTech and Moderna) are currently authorized for use in the United States. Recombinant vaccine technology inserts the genetic information for the spike protein into insect cells, which are then harvested, purified, and housed in nanoparticles.”

“A study in mice showed that removing gram-negative bacteria in the gut decreased the number of brain lesions in mice that were genetically susceptible to them. These type of bacteria release endotoxin (also called LPS) and this stimulates a very strong immune response leading to uncontrolled inflammation.”

“A diet containing compounds found in green tea (EGCG) and carrots (ferulic acid) reversed Alzheimer’s-like symptoms in mice genetically programmed to develop the disease. The dose used in animals was 30 mg per kg of body weight which is a human equivalent dose of 2.4 mg per kg of body weight.”

“Some of the participants were cognitively impaired, while others were not. The three cohorts provided data from clinical, neuropathological, imaging, cerebrospinal fluid, blood-based biomarker, and genetic assessments.”

“In the second part of the study, they analyzed genetic data of more than 500,000 participants enrolled in the UK Biobank study to determine how genetic markers that predict dietary omega-3 fatty acid levels correlate with lung health.”

“A new analysis asked whether this genetic difference shapes the relationship between blood omega-3 levels and early brain imaging markers. The study compared fasting blood omega-3 levels with two kinds of brain scans in 104 cognitively normal older adults.”

“Her research merges the varied genetic, environmental, and evolutionary forces that drive aging and age-related diseases, and identifies modifiable pathways that can mitigate basic aging processes.”

“This study (on 150 twin pairs) showed that the link between leg power and brain aging were not explained by genetics or shared environment. Additionally, other developmental, lifestyle and health measures indicated that reverse causation is not likely, and the effect is not likely to be mediated through frailty (as measured by telomere length), or disease.”