Search results for autoimmunity

“A series of meta-analyses involving 925 participants across 15 randomized placebo-controlled clinical trials explored the anti-inflammatory effect of quercetin supplementation in both healthy adults and people who had been diagnosed with a disease, including type 2 diabetes, metabolic syndrome, coronary artery disease, rheumatoid arthritis, and obesity.”

“Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD. Interview discussing the cellular clean-up program autophagy: Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation.”

“Reduced inflammation: BHB reduces inflammation due to chronic stress by inhibiting activation of the NLRP3 inflammasome, a potent proinflammatory pathway necessary for immunity to infection but implicated in autoimmunity.”

“A growing body of evidence indicates that the fasting-mimicking diet may be beneficial in treating autoimmune disorders. In these Aliquot segments, Dr. Rhonda Patrick and Dr. Valter Longo describe the roles that diet and fasting play in maintaining or restoring proper immune function.”

“The pivotal role fiber plays in fueling good bacteria in the gut that act like "miniature drug factories" which produce compounds that regulate the immune system by increasing the number of T regulatory cells, which are specialized types of immune cells that keep the immune system in check and prevent autoimmune responses.”

“Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.”

Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.

“A mouse study demonstrated that oral berberine (50 or 100 mg/kg/bw per day) reversed the depression-inducing effects of corticosterone injection by upregulating hippocampal synthesis of brain-derived neurotrophic factor – a type of protein that acts on neurons in the central and peripheral nervous systems and may be important for the antidepressant response.”

“Chronic inflammation and tissue injury at the BBB increases the risk of autoimmunity and neurodegeneration as immune cells encounter damage-associated molecular patterns and risk producing antibodies against self-antigens released from damaged CNS tissues.”

“Thus parents can steward the configuration of their child's microbiome, potentially reducing the risk of asthma, obesity, and other diseases in later life. In this clip, Dr. Eran Elinav discusses the importance of the early childhood period in shaping a healthy microbiome.”