Search results for brain

“Fibrinogen also activates the microglia, the brain’s resident immune cells. When inflammatory signals activate microglial cells, they switch from protecting the blood-brain barrier to attacking it. This promotes a vicious cycle of blood-brain barrier dysfunction and neurotoxicity.”

“Creatine plays a key role in maintaining cellular energy balance, and evidence suggests it can help the brain meet its high energy demands more efficiently. In Aliquot #131, The Muscle and Bone Benefits of Creatine, creatine expert Dr. Darren Candow and I discussed how creatine supplementation affects muscle quality, physical function, and even skeletal health, particularly in older adults.”

“The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrients and other beneficial molecules from the bloodstream into the brain while excluding harmful ones.”

“The discussion also explains why sleep and metabolic health belong in the same prevention framework. Deep sleep activates glymphatic clearance of metabolic waste, while impaired brain glucose metabolism is one feature of Alzheimer's disease.”

“Dr. Rhonda Patrick reviews structural and functional brain effects of alcohol. UK Biobank data associated greater intake with lower gray- and white-matter volume. Structure does not map perfectly to cognition, and association does not prove causation.”

“Studies in animals show that if Mfsd2a is defective or missing (which can happen with age or genetics), DHA levels in the brain decrease by more than 50%, potentially compromising the blood-brain barrier. In this clip, Dr. Axel Montagne describes the potential link between omega-3 fatty acids, inflammation, and brain health.”

“Dr. Mattson describes how human studies have demonstrated that brain cells rely mainly on glucose when carbohydrate intake is high. But a ketogenic diet causes the brain cells to switch, relying more on ketones, and less on glucose.”

“This clinical work supports the broader idea that ketones can help supply energy when brain glucose metabolism is impaired. Metabolic flexibility describes the capacity to shift between glucose and fat-derived fuels.”

“Dr. Phillips asserts that creatine monohydrate has been around for over forty years, and from a safety standpoint, the data he has reviewed looks good. In this clip, Dr. Stuart Phillips discusses creatine monohydrate and its effects on brain and muscle health.”

“In this clip from Dr. Rhonda Patrick's appearance on CrossFit Podcast, she explains why lactate is more than a waste product. Vigorous exercise rapidly increases lactate production, giving working tissues and the brain another fuel source while also participating in cellular signaling.”