Episode
Dr. Jari Laukkanen on Sauna Use for the Prevention of Cardiovascular & Alzheimer’s Disease
“Inflammation Inflammation is a key factor in the development of atherosclerosis and the progression to coronary heart disease. C-reactive protein (CRP), one of several blood proteins often referred to as acute phase reactants, participates in the inflammatory cascade.”
Fecal microbial transplants from young to old mice reverse the hallmarks of aging.
“Scientists have identified several hallmarks of aging – observable biological patterns of dysfunction that occur as an organism ages. These hallmarks both drive and are the result of inflammaging, the chronic, low-grade inflammation that occurs with aging.”
Episode
Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging
“00:48:27 - Inflammation as a harmful state sometimes mitigated by positive lifestyle changes and may be a unifying factor that brings together many of the promising avenues for boosting healthy telomere maintenance.”
More abdominal fat drives loss of fluid intelligence whereas more muscle mass protects against loss.
“Body composition describes an individual's body fat and lean mass. Excess body fat promotes systemic inflammation (which can promote neuroinflammation) and drives immune-related inflammatory processes. Lean muscle mass, however, may be protective against inflammation.”
A daily dose of coenzyme Q10—100 milligrams or less—reduces blood pressure by about 4mmH systolic and 3mmHG diastolic in people with type 2 diabetes, potentially lowering cardiovascular risk.
“These findings suggest that CoQ10 could be a useful addition to diabetes treatment for managing blood pressure and reducing cardiovascular risk. A common feature of diabetes and cardiovascular disease is inflammation.”
Traumatic brain injuries reactivate dormant herpes simplex virus, causing inflammation and accumulation of harmful proteins in the brain, a process potentially linked to Alzheimer's disease.
“A recent study found that TBIs can reactivate dormant herpes simplex virus type 1 (HSV-1), driving neuroinflammation and contributing to the development of Alzheimer's. Researchers created a three-dimensional model of the human brain.”
Urolithin A
“The mitochondria that were being cleared were simultaneously being replaced. Across several arms of the immune system the signal was that of a heightened immune response (when needed) without raising levels of baseline or chronic inflammation.”
A green tea polyphenol (EGCG) attenuated the progression of abdominal aortic aneurysm in a rat model. (2016)
“"Considering that abdominal arterial aneurysms are caused by inflammation and the degradation of elastin components in the arterial wall, we thought drinking green tea may show promise for treatment."”
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