Pathogenic gut bacteria migrate to the pancreas in patients with pancreatic cancer.
“The bacteria prevents the immune system from attacking tumor cells, accelerating tumor growth. The study found that bacteria that are more abundant in pancreatic cancers (including proteobacteria, actinobacteria, and fusobacteria) release lipopolysaccharides (which are bacterial cell membrane components) and this shifts the key immune cells in the pancreas into immune suppression.”
Possible link between COVID-19 and acute appendicitis in children.
“The authors of the report proposed three reasons for the possible connection between SARS-CoV-2 infection and acute appendicitis: gastrointestinal symptoms of COVID-19 are fairly common in children; the SARS-CoV-2 virus tends to linger in the gut long after the initial infection; and the ACE-2 receptor (the means by which SARS-CoV-2 gains entry into cells) is present throughout the gut…”
Probiotic was engineered to make an enzyme able to produce sulforaphane from the precursor in broccoli extract. It reduced tumor size by over 75%.
“This is pretty clever because they modified the e.coli to bind to cancer cells. One issue w/ broccoli extract is that the conversion to sulforaphane in vivo depends on gut bacteria, usually resulting in different bioavailability from person to person.”
Daily apple consumption decreases multiple markers of obesity-associated inflammation.
“Plant foods such as apples are beneficial for people with obesity because they are rich in bioactive compounds that decrease inflammation and dietary fibers that strengthen the gut barrier.”
Butyrate receptor in colon functions as tumor suppressor.
“Findings from a 2009 study suggest that butyrate, a short-chain fatty acid, activates a protein called GPR109A in the colon to suppress colon cancer. Short-chain fatty acids are produced by the gut microbiota during the fermentation of dietary fiber.”
Probiotics may improve inflammation-associated behavioral changes in mice by lowering TNF-alpha blood levels. (2015)
“The gut-brain axis, a bidirectional signaling pathway between the gastrointestinal tract and the nervous system, plays critical roles in human health. Key elements of this pathway are the tens of trillions of microbes that comprise the intestinal microbiota.”
Fecal microbiota transplantation from young mice reverses aging effects.
“Declines in brain function are common with age owing to metabolic and immune alterations that include changes to the gut microbiota, the community of microorganisms that inhabit the intestines.”
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