Search results for cognition

“Across small trials, creatine has shown a modest memory benefit, while effects on overall cognition and executive function remain less consistent. This makes brain energy under severe sleep loss a promising research setting without defining one universal cognitive dose.”

Dr. Rhonda Patrick explains creatine for training and explores brain energy, cognition during severe sleep loss, and product quality.

“These clinical settings differ from healthy aging, but they add human evidence that lactate can be a usable brain fuel alongside the BDNF and cognition signals seen after vigorous exercise. This clip is excerpted, with permission, from Dr. Rhonda Patrick's appearance on Thomas DeLauer's podcast.”

“00:20:21 - Some of the key blood-based biomarkers that are useful for tracking and projecting future cognitive health, including: homocysteine (<7μml/L preferred), which Dr. Bredesen indicates may be a mediator of cerebral atrophy, and also fasting insulin (<5% preferred), hemoglobin A1c, fasting glucose, vitamin D, and a number of other hormones relevant for trophic support.”

Dr. Rhonda Patrick and Dr. Peter Attia discuss creatine dosing, cognition under stress, product quality, and muscle performance.

“The brain also uses creatine, although its uptake and cognitive effects vary. A meta-analysis of 16 small trials found modest benefits for memory and selected timed outcomes, with less consistent effects across overall cognition and executive function.”

“Brain response varies with baseline diet, age, dose, and physiological stress. A meta-analysis of 16 randomized trials found a modest benefit for memory, while effects on overall cognition and executive function were not significant.”

Dr. Rhonda Patrick examines how vitamin D status relates to gene regulation, epigenetic aging, cognition, and dementia risk.

“Three COSMOS cognitive substudies found small improvements in global cognition and episodic memory among older adults who received a standard multivitamin. Vitamin D supplementation can help correct low vitamin D status, which is influenced by sun exposure, skin pigmentation, season, latitude, and other factors.”

“Lactate is a fuel and inter-organ signal, not merely a waste product. Human work links higher exercise lactate with circulating BDNF and selected acute executive-function outcomes, while animal and mechanistic studies support possible effects on neurogenesis.”