Search results for mitochondria

“The authors went on to posit that the similarities between obesity and aging are driven by shared molecular- and cellular-level mechanisms, including increased levels of reactive oxygen species, mitochondrial dysfunction, cellular senescence, increased apoptosis, impaired autophagy, and increased inflammation.”

“However, because this study utilized a small sample, reported large variations in the data, and did not contain a control group, these results must be replicated with future research before they can be fully interpreted. Link to full publication.”

“Next, they tracked the movement of butyrate in the animals' bodies and determined that it traveled quickly from the gut to the skin (about 45 minutes), where it directly influenced the mitochondrial metabolism of keratinocytes, the dominant cell type in the epidermal layer of the skin.”

“The team also measured cardiorespiratory fitness using peak oxygen uptake (VO2peak), and examined potential mediators at baseline and 12 months: body mass index, body fat and waist measures, blood pressure, and plasma brain-derived neurotrophic factor (BDNF, a protein that helps support nerve cell health and communication).”

“When exposed to beta-hydroxybutyrate, pre-diet white blood cells associated with the innate immune system (the driver of chronic low-grade inflammation) did not alter their behavior; however, antibody-producing white blood cells associated with the adaptive immune system became more active.”

“Sulforaphane exerts its therapeutic effects through a variety of mechanisms, the most notable of which is the activation of Nrf2, a cellular protein that regulates the expression of antioxidant and stress response proteins that provide protection against oxidative stress due to injury and inflammation.”

“Because this genetic analysis reflects lifelong caffeine exposure rather than a specific intake level, it cannot indicate an effective dose, and its reliance on only two variants from mostly European datasets further limits precision.”

“The multivitamin also affected parts of the epigenetic clock GrimAge, with changes in DNA patterns linked to telomere length (the protective caps at the ends of chromosomes) as well as beta-2 microglobulin, cystatin C, and growth differentiation factor 15, which are markers associated with inflammation, kidney function, and mitochondrial dysfunction.”

“A ketogenic diet reprogrammed metabolism and the immune system to a greater extent in older mice by increasing the number of beneficial T cells and reducing the number of harmful monocytes in the lungs, leading to less inflammation overall and reduced disease severity.”

“The researchers measured body temperature using infrared thermography, body composition using x-ray absorptiometry, and oxygen consumption during a strenuous cycling exercise, a measure of maximal metabolic rate.”