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“Cholesterol-lowering drugs can act at several points in the body's handling of lipoproteins. Dr. Rhonda Patrick compares PCSK9 inhibitors, bempedoic acid, and ezetimibe, focusing on how they reduce circulating LDL and apoB-containing particles.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“If you rapidly start a ketogenic diet, you are more likely to experience side effects including disrupted sleep and lipid abnormalities. Dr. D'Agostino asserts that transitioning to the diet by titrating carbohydrates down gradually improves adherence and tolerance.”

“Mitochondrial health and overall health are intrinsically linked. Identifying ways to boost mitochondrial biogenesis – the formation of new mitochondria – ensures that cells maintain an adequate number of mitochondria to meet their energy needs.”

Dr. Rhonda Patrick discusses nicotinamide riboside, biomarkers, belly fat loss, sex-specific health, curcumin & ashwagandha safety.

“Exercise is a huge driver of how well we age because it induces profound molecular shifts that support immune health and might even protect our telomeres – indicators of aging. Exercise might help forestall certain age-related diseases, such as Parkinson's disease, too.”

“In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including: What effects coffee, supplements, and amino acids have on fasting. Whether one method of fasting is more beneficial than others.”

“In particular, he monitors his ketone levels, both upon waking and following exercise. Tim maintains that not everyone processes ketones to the same extent, and he prefers to tailor his ketone level to allow maximal mental clarity.”

“Dr. D'Agostino asserts that a low carbohydrate diet incorporating intermittent fasting probably has more benefits than chronic ketosis for most healthy adults. Drs. D'Agostino and Patrick describe their experiences with fasting or time-restricted eating and its calming effects on the brain.”

“Time-restricted eating, in particular, has the potential to realign the body's circadian rhythms. In this clip, Dr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each.”