Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction
“Study used a silk thread to create an animal model of "bladder outlet obstruction (BOO)," which is a condition affecting nearly 30% of men over the age of 60 and usually caused by benign prostatic hyperplasia (BPH).”
Episode
Joe Rogan Experience #901 - Dr. Rhonda Patrick
“00:37:40 - Sulforaphane is the most potent naturally-occurring activator of the Nrf2 pathway. Study. 00:39:10 - Sulforaphane slowed the progression of prostate cancer.”
A large clinical trial is underway to investigate the effects of exercise on cancer progression and treatment in men with advanced prostate cancer.
“Studies in animals have shown that aerobic exercise slowed the growth of breast cancer tumors 1.5 times more than sedentary animals. Exercise also made the cancer cells much more sensitive to chemotherapy and the combination of the two had the most significant impact in reducing tumor size.”
Eating carotenoid-rich foods may lower your blood pressure.
“Beta carotene is found in carrots, sweet potatoes, and winter squash. Epidemiological data suggest that consumption of carotenoid-rich foods reduces the risk of many diseases, including type 2 diabetes, macular degeneration, and prostate cancer.”
women with blood levels of vitamin D in the 60 ng/ml range had an 80% lower breast cancer risk compared to women with less than 20 ng/ml.
“Another randomized controlled trial found that men given 4,000 IU of vitamin D per day slowed cancer progression and improved tumors in men with low-grade prostate cancer (compared to men given placebo).”
Nrf2 pathway is a major target for sulforaphane.
“Sulforaphane, an isothiocyanate derived from broccoli and broccoli sprouts, is the most potent naturally occurring inducer of Nrf2. The authors of the review presented evidence that sulforaphane protects against carcinogenesis in models of skin, oral, stomach, colon, lung, prostate, and bladder cancer.”
Results 51–60 of 130