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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, the mechanisms behind how it works, and the bottom line on resveratrol supplementation and safety. A few key moments... For a more in-depth timeline, as well as references for this episode, click the timeline tab. Learn more about resveratrol on our overview page”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Whereas its link to diabetes is well known, what is likely underappreciated is that refined sugar may be linked to as many as 200,000 deaths worldwide each year from diabetes, cardiovascular disease, and cancer combined. Refined sugar also affects the brain.”

“Unique qualities of the marine omega-3 fatty acids EPA and DHA There are several omega-3 fatty acids, but the ones that have the greatest relevance for human health are the two identified in the Inuit's blood – EPA and DHA – as well as alpha-linolenic acid (ALA), which is found in a wide variety of seeds, nuts, and their oils.”

“01:36:35 - How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it. 01:52:28 - Peter's 80% zone 2 / 20% VO2 max training protocol.”

“Although human trials are lacking, some animal research suggests that sulforaphane and its byproducts protect against bladder cancer. In this clip, Dr. Jed Fahey discusses the effects of urinary excretion of sulforaphane byproducts.”

“Although human trials are lacking, some animal research suggests that sulforaphane and its byproducts protect against bladder cancer. In this clip, Dr. Fahey describes the metabolic fate of sulforaphane and the current state of research on its effects against bladder cancer.”

“Sulforaphane activates NRF2-regulated cellular defense pathways. In a randomized crossover trial of 60 adults, eating 85 grams of raw watercress daily for eight weeks reduced basal lymphocyte DNA damage by 17% and oxidative purine DNA damage by 23.9%.”

“an 11–54% lower risk of oral, pharynx, colon, prostate cancer and melanoma. Mechanistically, coffee actively protects cells by reducing DNA damage, specifically DNA double-strand breaks, which are particularly damaging and cancer-promoting.”