Search results for apoptosis

“Mitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis (programmed cell death). As a result, mitochondrial health is intrinsically linked to overall health.”

“For example, moderate stressors may switch on stress-resistant genes, while more intense stressors may switch on genes that drive apoptosis by recruiting death cytokines like Fas ligand and TRAIL.”

“Autophagy differs from apoptosis, a type of cellular self-destruct mechanism that rids the body of damaged or aged cells. However, the two processes are governed by shared signals and regulatory components, blurring the lines between their activities.”

“In the intestine, berberine appears to be beneficial in reducing factors that drive inflammatory conditions. In cell culture studies, berberine reduced pro-inflammatory cytokines and apoptosis in the gut – two hallmarks of inflammatory bowel disease.”

“When the telomeres on a cell's chromosomes get too short, the chromosome reaches a "critical length," and the cell stops dividing (senescence) or dies (apoptosis). Shorter telomeres leave DNA more vulnerable to mutations.”

“Without oxygen, the heart’s cells undergo apoptosis and necrosis, or cell death. As cells die, they release proinflammatory signals that worsen cellular and tissue damage. This cardiac cascade can lead to long-term reductions in the heart’s pumping efficiency and, eventually, heart failure.”

“Cytotoxic T (Tc) cells deliver molecular signals that induce cellular death (i.e., apoptosis) to foreign cells, cancer cells, and cells infected with intracellular bacterial and viral pathogens.”

“This long-term food deprivation can induce a unique set of metabolic events, such as more profound ketosis, as glycogen stores are depleted, potentially promoting cellular and systemic clean-up through programs such as apoptosis and autophagy.”

“Cancer suppression: BHB activates tumor suppressor p53, a protein that regulates DNA repair, cell growth, apoptosis, and senescence. Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases.”