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“The researchers also think that T-cells may first identify alpha-synuclein in the nervous system of gut then enter the brain where they begin attacking dopaminergic neurons. These findings raise the possibility for an immunotherapy-based treatment.”
“Day 1-prefasting consists of an 800 kcal (about 40% of normal caloric intake similar to mouse Day1 FMD) monodiet (fruit, rice, or potatoes) by preference of individuals. On the following day patients were recommended to use an oral laxative, Natrium Sulfuricum (20-40 g).”
“Stable glucose despite lower insulin indicates better insulin sensitivity, while the lower heart-rate response during exercise and faster muscle oxygen recovery suggest more efficient blood flow regulation and oxygen delivery or use.”
“In small doses, stress can sharpen focus and improve resilience, but chronic stress gradually erodes emotional stability, increasing the risk of major depressive disorder. A recent study found that autophagy—the brain's recycling and housekeeping system—helps maintain emotional stability by removing old or damaged proteins.”
“Spermidine causes damaged cells to be cleared through a process known as autophagy which has itself been shown to extend healthspan of animals. In this study, mice had to be fed spermidine from weaning in order to get the 25% lifespan extension.”
“Episodic memory, which records specific events, situations, and experiences, declines with age, but this loss may be impeded by certain lifestyle interventions, such as caloric restriction.”
“Unlike ordinary autophagy, which generally recycles various cell parts, CASA specifically targets and breaks down damaged or misfolded proteins with the help of unique proteins called chaperones. BAG3 is one of these chaperones.”
“Mice that ate on a time-restricted schedule had fewer active genes involved in inflammation and oxidative stress and more active genes involved in metabolism and autophagy – a cellular defense mechanism.”
“Extra-virgin olive oil protects nerve cell structure and function, improves learning and memory, and reduces the amyloid-beta plaques and neurofibrillary tangles in the brain in mice genetically engineered to get Alzheimer's disease.”
“In older neurons, reduced GTP levels may slow these steps. Nicotinamide may help restore the cell's energy capacity, while EGCG may activate protective genes through the Nrf2 pathway, helping maintain the conditions needed for transport and recycling to function properly.”