Related Topic Articles for Omega-3 Index

“Assessments of episodic memory based on a battery of cognitive tests demonstrated that the rate of cognitive decline experienced by healthy, older people who had amyloid-beta protein accumulation in their brain and who were APOE4 and BDNF Met carriers was roughly three times the rate of decline among those carrying only the BDNF Val allele (the more common form of the gene that retains valine).”

Biological aging clocks use DNA methylation patterns and other biomarkers to estimate different dimensions of biological aging, including how old the body appears at the molecular level, how quickly aging-related changes are accumulating, and whether lifestyle or medical interventions may be changing the trajectory of aging.

“DAMPs such as HMG-1 bind to TLR4 and receptors for advanced glycation end products (RAGE) on cells at the blood-brain barrier to induce an immune response that initially inhibits the deposition of amyloid-beta, a key feature of Alzheimer's disease progression.”

“Neurogenesis Whereas the early view of the mammalian central nervous system presumed that it was a static complex incapable of change, a growing body of evidence suggests that it retains its capacity for synaptic pruning – the process that eliminates extra neurons and synaptic connections and establishes new neural circuits to increase the efficiency of neuronal transmissions – throughout life.”

“Multiple age-related inputs can keep innate immune pathways active, including the senescence-associated secretory phenotype, mitochondrial damage and oxidative stress, debris released by injured cells, visceral adipose tissue inflammation, chronic infections, increased intestinal permeability, and dysbiosis.”

“In an attempt to control for the healthy user bias (the possibility that people who take multivitamins may have better lifestyle habits than nonusers), the statistical analyses were adjusted for confounding factors like age, sex, education, alcohol and tobacco use, BMI, physical activity, diet quality, family history of cancer, and the use of other supplements.”

Omega-3 fatty acids play critical roles in human health and may be beneficial in ameliorating symptoms associated with chronic health conditions and in combating aging-related diseases.

“Interestingly, a recent randomized controlled trial showed that pregnant women who supplemented with 600 milligrams of DHA during their third trimester had sons with larger total brain volumes, total gray matter, corpus callosum, and cortical volumes when compared to boys born to mothers who took a placebo.”

Small vessel disease is a generic term that describes dysfunction of blood vessels that occurs with aging and contributes to cognitive decline, cardiovascular disease, frailty, and stroke.

Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.