FoundMyFitness library
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“Multiple age-related inputs can keep innate immune pathways active, including the senescence-associated secretory phenotype, mitochondrial damage and oxidative stress, debris released by injured cells, visceral adipose tissue inflammation, chronic infections, increased intestinal permeability, and dysbiosis.”
“If you focus on eating multiple protein-containing meals each day and are thoughtful about your sources, it's likely you'll meet daily protein needs and thrive, whether your goal is gaining more muscle or just staying strong into your later years.”
“Increased intestinal permeability (also known as "leaky gut") – a condition in which gaps form between the tight junctions that join enterocytes – allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation through a specialized mechanism involving detection by toll-like receptors.”
“Conclusions Lactobacillus reuteri has demonstrated a plethora of unique biological effects across a wide range of clinical and non-clinical research that seemingly converge on a few fundamental mechanisms, including strengthening the gut barrier and immune system, improving metabolism, and protecting infants from digestive diseases, among others.”
“In a recent double-blind placebo-controlled trial involving 27 healthy older adults (average age, 62 years) with at least one risk factor for diabetes, each of the study participants engaged in three 45-minute aerobic exercise training sessions per week for 12 weeks using a treadmill, stationary cycle, or elliptical machine.”
“In an attempt to control for the healthy user bias (the possibility that people who take multivitamins may have better lifestyle habits than nonusers), the statistical analyses were adjusted for confounding factors like age, sex, education, alcohol and tobacco use, BMI, physical activity, diet quality, family history of cancer, and the use of other supplements.”
“Compared with no resistance training, 90–119 minutes per week was associated with a 13% lower rate of death from any cause, a 19% lower rate of cardiovascular death, and a 27% lower rate of neurological disease death after accounting for aerobic activity and other health and lifestyle factors.”
“Using isotope tracers that allowed them to distinguish NAD+ made directly from NR or NMN versus NAD made from nicotinamide, NR, or NMN, they found that a low oral dose of the precursors (50 milligrams per kilogram body weight, mg/kg/bw) produced very low levels of NAD+ made directly from NR and NMN in the liver but not in other tissues.”
“For example, a large, population-based study that drew data from more than 170,000 men and women between the ages of 30 and 75 years showed that animal protein intake was associated with increased death rates only when the participants had at least one unhealthy lifestyle risk factor such as smoking, heavy alcohol consumption, physical inactivity, or being overweight or obese.”
“In a study involving diet-induced diabetic mice, injection of 500 milligrams per kilogram of body weight (mg/kg/bw) of nicotinamide mononucleotide administered for seven days enhanced insulin sensitivity and improved glucose intolerance compared to that observed among mice not given nicotinamide mononucleotide.”