Related Episodes for How Supplements May Support Brain Health With Age

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“A meta-analysis restricted to direct regional measures from MRI, CT, or ultrasound found a very small average hypertrophy benefit when creatine was combined with resistance training, with uncertainty around the pooled estimate and variation across sites and populations.”

“In a four-month randomized trial of 88 overweight, untrained middle-aged adults, daily doses of 500 or 1,000 milligrams improved some muscle and mitochondrial measures, while the primary outcome of peak power did not significantly improve.”

“Choosing a supplement that contains both glucoraphanin (the precursor to sulforaphane), as well as myrosinase (the enzyme that converts glucoraphanin to sulforaphane), is crucial to ensuring optimal sulforaphane delivery.”

“In more than 2,000 adults ages 51 to 80, higher Sitting-Rising Test scores were associated with longer survival, making floor-transfer ability a useful marker of functional capacity. Floor time can include cross-legged sitting, kneeling, side-sitting, or sitting with the legs extended.”

“The fact that poor sleep is linked with the aggregation of amyloid-beta plaques in the brain and Alzheimer's disease is not surprising. Although some strategies for improving the quality of sleep among people with Alzheimer's have been identified, this might be too late to turn the tide of cognitive decline.”

“In this clip, Dr. Michael Snyder discusses how people age in distinct ways and at varying rates and how knowing our "ageotype" might offer targets for preventing age-related diseases.”

“In this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists. Dr. Levine shares the hallmarks of aging that help researchers determine someone's biological age, what drives accelerated aging, and what epigenetic modifications such as CpG methylation say about the aging process.”