Related Episodes for The connection between Alzheimer’s disease and insulin resistance | Peter Attia

“Sprint-interval exercise improved reaction time on selected executive-function tasks for about 10 to 30 minutes in a controlled study, supporting Dr. Patrick's practice of using a short workout before an early talk or demanding meeting.”

“The research, spearheaded by Professor John Little at the University of British Columbia, is still in the preliminary stages, with two randomized controlled trials underway to ascertain the regimen's efficacy over 12 weeks.”

“Exercise can improve blood pressure, insulin sensitivity, triglycerides, and fitness, but someone with high ApoB or LDL may still need targeted diet changes and clinician-guided lipid-lowering treatment. Mood is another major benefit.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“Dr. Patrick then prioritizes lower-glycemic-load, less-refined foods and adequate fiber. Early time-restricted eating can help some people reduce calories and may influence selected metabolic markers, but it is not required and must still preserve protein and diet quality.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“Visceral fat can respond to changes in energy balance and physical activity. A meta-analysis of 40 randomized trials and 2,190 adults with overweight or obesity found that both exercise and calorie restriction reduced CT- or MRI-measured visceral fat.”

“During about eight years of follow-up, the models associated one vigorous minute with roughly 4.1 moderate minutes for all-cause mortality, 7.8 minutes for cardiovascular mortality, and 9.4 minutes for type 2 diabetes risk.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”

“Across the modeled dose-response curves, one vigorous minute corresponded to 4.1 moderate minutes for all-cause mortality, 7.8 for cardiovascular mortality, 5.4 for major cardiovascular events, 9.4 for incident type 2 diabetes, and 3.5 for cancer mortality.”