Related Episodes for The role of fasting-induced ketosis in stem cell activation and cell renewal | Valter Longo

“Moreover, taking mega doses (i.e. 400 IU/day) of alpha tocopherol has the unintended side-effect of actually depleting tissue levels of another important form of vitamin E that plays an anti-inflammatory role, known as gamma tocopherol.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“Dr. Patrick describes increased shear as a possible way vigorous exercise can damage fragile circulating tumor cells; this is a proposed mechanism, not proof that a workout eliminates metastasis or treats an established tumor.”

“In 25,241 adults who reported no structured exercise, a median of three one- or two-minute vigorous lifestyle bouts per day was associated with 38% to 40% lower all-cause and cancer mortality and 48% to 49% lower cardiovascular mortality.”

“Dr. Patrick also describes a proposed anti-metastatic mechanism: faster blood flow during vigorous exercise increases shear forces on circulating tumor cells, the cells that have left a primary tumor and entered the bloodstream.”

“In this excerpt from Dr. Rhonda Patrick’s A4M LongevityFest 2023 keynote, she reviews a randomized trial in sedentary middle-aged adults. Two years of progressive, supervised aerobic training increased VO2 max and reduced left-ventricular stiffness.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“Gaining FDA approval of psilocybin under these conditions is problematic, however, due to the negative connotations associated with the compound's use and the potential for harm when used in vulnerable populations.”

“His lab also developed a technique for harvesting 5 to 7 times more hematopoietic stem cells from placenta than is currently retrieved from cord blood, a more standard, established source that is used worldwide for bone-marrow transplant.”

“In a UK Biobank study of 25,241 adults who reported no leisure-time exercise, about three daily bouts lasting one or two minutes were associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”