Related Episodes for Nutrigenomics, Epigenetics, and Stress Tolerance (IHMC Talk #1)

“Melatonin appears in the comparison as a personal, goal-specific choice rather than a universal nightly supplement. Dr. Patrick also discusses glycine, collagen, myo-inositol, and other non-overlapping items with different levels of evidence.”

“In a randomized trial of 57 children with autism spectrum disorder, a caregiver-rated secondary behavior scale improved and biomarker changes involved glutathione, mitochondrial, inflammatory, and heat-shock pathways, while the primary clinical outcome was similar between groups.”

“A separate trial of 153 adults found that smartphone-based mindfulness training combining attention monitoring with acceptance reduced daily loneliness and increased social interactions compared with monitoring alone or an active control.”

“In this FoundMyFitness Premium Q&A preview, Dr. Rhonda Patrick reviews common contributors to fragmented sleep, including insomnia, sleep apnea, nocturia, psychological stress, irregular schedules, caffeine, alcohol, light, noise, temperature, and late eating.”

“Family-controlled research provides another view. A Swedish cohort of 2.48 million children found small associations in conventional models, but the estimates moved to the null when siblings with different prenatal exposure were compared.”

“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”

“More than 200 HMOs have been identified, and they are the third most abundant factor in breast milk after fat and lactose. The primary role of HMOs is to serve as prebiotics – compounds that induce the growth or activity of beneficial bacteria.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“Use of these substances is often carried out in a highly controlled cultural context for religious or healing purposes or for divination and not casual use. The use is often accompanied by strong mystical experiences that have great significance to the user.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”