Related Episodes for Immune stimulation may treat depression via cytokines that boost neurotrophic factors | Charles Raison

“There is so much to say when we talk about the NRF2 pathway and isothiocyanates like sulforaphane that we had to pack it into 47 minutes and break it into a few key sections. Key sections: For a more in-depth breakdown click the timeline link at the top of this page!”

“Inflammation is a critical element of the body’s immune response. Chronic inflammation, which occurs on the cellular level in response to toxins or other stressors, plays a key role in the development of many diseases, including depression.”

“Researchers treated patients with major depressive disorder with heat so that their core body temperature reached temperatures equivalent to those experienced with sauna use. Following just one treatment session, subjects experienced elevations in mood that lasted for several weeks.”

“Five grams of creatine per day increased total sleep duration on resistance-training days compared with placebo, while the groups did not differ in overall sleep quality. The result introduces sleep as a promising new area of creatine research.”

“Since then, countless studies have tested Pauling's theories about vitamin C, colds, and cancer (and many others), and a substantial body of evidence has emerged, identifying critical roles for vitamin C in immune function, cardiovascular and respiratory health, cognitive development and preservation, and many other aspects of human health.”

“Other cohorts report null or apparently protective associations that can reflect sick-quitter bias, socioeconomic differences, cardiometabolic health, and drinking pattern. APOE4 may modify vulnerability in some studies, but interactions are inconsistent.”

“Rebuilding muscle relies on proper nutrition and exercise, but aging reduces the body's response to both. Extended periods of inactivity, such as post-surgery or during illness, can rapidly deplete muscle mass, especially in older people, potentially pushing them into a "catabolic crisis."”

“In this Aliquot, Drs. Axel Montagne, Matthew Walker, Mark Mattson, Valter Longo, Peter Attia, and I discuss the risks associated with high blood pressure and describe some of the many ways lifestyle can help achieve and maintain healthy blood pressure.”

“Some studies suggest cheese may lower the risk of dementia and heart disease, despite its saturated fat content—raising questions about the effects of food structure, fermentation, and individual differences in metabolism.”

“In this Aliquot, I'm joined by Drs. Martin Gibala, Luc van Loon, and Brad Schoenfeld to break down how to manage load, train in joint-friendly ways, reduce inflammation, and separate supplements supported by evidence from those that remain uncertain.”