Related Episodes for How amino acids like leucine drive mTOR and affect muscle mass | Peter Attia

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“In a small immobilization trial, five grams per day of omega-3 fatty acids reduced the loss of muscle volume in young women compared with sunflower oil, supporting continued research on omega-3s and disuse atrophy. Heat is the fourth proposed tool.”

“A randomized-trial meta-analysis found a higher atrial-fibrillation risk with marine omega-3 supplementation, with a stronger signal at doses above 1 gram per day; the included populations generally had cardiovascular disease or elevated cardiovascular risk.”

“Xenotransplantation, the practice of transplanting an organ from a non-human animal, such as a pig or chimpanzee, to a human, has its origins in the 1960s. Among six patients receiving kidney xenotransplants from chimpanzees in 1963, one survived for nine months in moderate health.”

Dr. Levine shares personal habits she has developed to slow aging, including exercise, a plant-based diet, and time-restricted eating.

“A few examples of genes with common polymorphism discussed are MTHFR and folate, NBPF3 and vitamin B6, FUT2 and vitamin B12, BCMO1 and beta-carotene, FADS2 and omega-3 fatty acids, CYP2R1 and vitamin D, PEMT and choline as well as APOE4 and FOXO3.”

“However, upon refeeding only lean muscle mass is regenerated. The overall result, a loss of visceral fat without depleting lean muscle mass, is a desirable feature of a prolonged fast, particularly for athletic performance.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.