Related Episodes for Managing and detecting the exposome and exposure to air pollution | Dr. Michael Snyder

“Mounting evidence suggests that exploiting this property may be useful towards reducing the toxicity of chemotherapeutics while also maximizing their impact in the treatment of cancer.”

“An emerging strategy in the prevention and (possibly) treatment of neurodegenerative diseases is starving cells as a means to induce general autophagy to help rid the cell of protein aggregates.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“A small magnetic-resonance spectroscopy study also found that 20 grams per day for four weeks increased brain creatine by an average of about 8.7 percent, showing that brain uptake is possible but variable.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“This is a proposed metabolic advantage, not proof of slower brain aging. Small TBI trials found that sodium lactate lowered intracranial pressure more than mannitol in severe TBI and improved cognitive scores more than 3% sodium chloride in mild TBI.”

“Smaller crossover studies support the same practical direction. Sprint intervals improved the late insulin response after one four-hour night of sleep, and a two-week HIIT program attenuated the rise in glucose, insulin, and free fatty acids after 24 hours without sleep.”