Related Episodes for Rethinking GLP-1 Drugs for Weight Loss and Long-Term Health

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

“Dr. McGlory sheds light on the relationship between aerobic conditioning and muscle hypertrophy, addressing the notion that aerobic exercise might hinder muscle growth gained through resistance training.”

“Limiting evening light exposure, decreasing the temperature of the room in which we sleep, reducing our anxiety, and restricting the intake of substances that alter our alertness can have demonstrable effects on improving our sleep.”

“FGF21 is a preliminary liver-brain signal in this discussion. A small human laboratory study found a robust rise in serum FGF21 after a two-hour alcohol self-administration session in 16 people with alcohol use disorder; it did not test exercise or craving treatment.”

“Rebuilding muscle relies on proper nutrition and exercise, but aging reduces the body's response to both. Extended periods of inactivity, such as post-surgery or during illness, can rapidly deplete muscle mass, especially in older people, potentially pushing them into a "catabolic crisis."”

“However, dietary strategies, pharmaceuticals, and some supplements may reduce ApoB levels. In this Aliquot – a follow-up to Aliquot #81 – Dr. Peter Attia and I talk about some of the nutritional, pharmaceutical, and supplemental approaches to reduce ApoB.”

“Beyond its role in sexual development, testosterone is important for overall health, influencing mood, energy levels, and even cognitive function. Testosterone is also a highly contested topic, especially in the context of resistance exercise, lifestyle, and managing low testosterone.”

“In this Aliquot, cardiologist Ben Levine, nutritional scientist and champion powerlifter Layne Norton, and I discuss the importance of recovery, how best to approach it, and some surprising, often overlooked aspects of this important part of fitness.”

“Part 3 of this series focuses on maximizing and maintaining muscle mass—an essential part of long-term health and fitness—with insights from exercise physiologist and nutrition expert Dr. Luc van Loon and exercise scientist Layne Norton.”

“Some studies suggest cheese may lower the risk of dementia and heart disease, despite its saturated fat content—raising questions about the effects of food structure, fermentation, and individual differences in metabolism.”