Related Episodes for Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging

“Additionally, we also discuss the important role magnesium plays in preventing random mutations. "Men with the highest quartile of magnesium levels have a 40% decrease in all-cause mortality and a 50% decrease in deaths from cancer.".”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

Dan Pardi: Ph.D. candidate studying sleep neurobiology at Stanford and University of Leiden, co-founder of Dan’s Plan online wellness company.

“A critical element in healthiness is the timing and content of our meals. Time-restricted eating, a form of daily fasting wherein the time of the day during which a person eats is limited, capitalizes on the body's natural circadian metabolic rhythms to promote health.”

“Moreover, taking mega doses (i.e. 400 IU/day) of alpha tocopherol has the unintended side-effect of actually depleting tissue levels of another important form of vitamin E that plays an anti-inflammatory role, known as gamma tocopherol.”

“For example, growing up in an overly hygienic environment increases a child's risk for developing autoimmune diseases, but exposure to dirt, especially from soil, pets, and roaches, in the first year of life may provide protection against asthma and allergy-related skin disease.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“A larger randomized-trial meta-analysis also found modest average reductions in BMI, waist circumference, and body-fat percentage, although protocols and populations varied. These averages do not mean that HIIT alone guarantees fat loss.”

“Gaining FDA approval of psilocybin under these conditions is problematic, however, due to the negative connotations associated with the compound's use and the potential for harm when used in vulnerable populations.”