Cholesterol
Episodes
Dr. Rhonda Patrick discusses coffee's remarkable ability to slow biological aging, reduce DNA damage, and lower cancer risk.
Dr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.
Dr. Rhonda Patrick discusses saturated fats and LDL, luteolin's benefits, glyphosate risks, natural vs. artificial flavors, and black cumin seed effects.
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Dr. Rhonda Patrick discusses coffee's remarkable ability to slow biological aging, reduce DNA damage, and lower cancer risk.
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Alzheimer's Technology Cancer Nootropics Cholesterol Omega-3 Melatonin Vaccine Polyunsaturated Fat SupplementsDr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.
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Cancer Hormones Diabetes Cholesterol Omega-3 Inflammation Polyunsaturated Fat COVID-19 TBI SupplementsDr. Rhonda Patrick discusses saturated fats and LDL, luteolin's benefits, glyphosate risks, natural vs. artificial flavors, and black cumin seed effects.
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Rhonda Hormones Diabetes Cholesterol Omega-3 Dementia Curcumin Protein Blood Sugar Berberine AcetaminophenDr. Rhonda Patrick discusses xylitol safety, strategies to reduce hemoglobin A1C, klotho and dementia risk, and the timing of hormone replacement therapy.
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Dr. Rhonda Patrick discusses fish oil and Afib risk, hyperbaric oxygen therapy, supplements for kids, and curcumin's impact on testosterone.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Rhonda Vitamin D Exercise Brain Alzheimer's Parkinson's Cancer Microbiome Cholesterol Omega-3 Skin Sulforaphane Protein NAD+ Moringa Blood-Brain Barrier CocoaDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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In this clip, Dr. Ronald Krauss discusses that in clinical practice, cholesterol particle size may be more relevant than the amount of cholesterol.
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In this clip, Dr. Ronald Krauss discusses the complexities of HDL cholesterol and its relationship to heart disease risk.
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In this clip, Dr. Ronald Krauss discusses the possible protective role of LDL cholesterol.
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In this clip, Dr. Ronald Krauss describes why it may be more beneficial to reduce LDL levels than to raise HDL levels.
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In this clip, Dr. Ronald Krauss debunks common myths of dietary cholesterol and saturated fat.
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In this clip, Dr. Ronald Krauss shares his experience in research showing heart disease risk is more influenced by sugar consumption than fat consumption.
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In this clip, Dr. Ronald Krauss explains how simple sugars are the culprit for many of the diseases he has studied.
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Dr. Krauss believes that the future of research funding should come from philanthropic sources that eliminates any risk of conflicts of interest.
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In this clip, Dr. Krauss discusses how statins reduce the risk of cardiovascular disease and potential for better drugs in the future.
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Dr. Krauss explains that he believes both are impactful for correcting LDL levels and mitigating risk of cardiovascular disease.
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In this clip, Dr. Krauss shares his thoughts on the prescription pattern of statins in the United States.
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In this clip, Dr. Krauss talks about the necessity of the ion mobility test before starting statin therapy and the growing popularity of the test.
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In this clip, Dr. Krauss discusses the indications for the ion mobility test.
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In this clip, Dr. Krauss talks about LDL numbers that are considered high risk.
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In this clip, Dr. Eran Elinav describes research suggesting that the microbiome modulates fatty acid metabolism.
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In this clip, Dr. Bill Harris describes his early research using high doses of omega-3 fatty acids, which uncovered their surprising effects on triglycerides.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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In this clip, Dr. Michael Snyder describes how the human microbiome plays a key role in health, immunity, and nutrition.
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Rhonda Exercise Aging Sleep Telomeres Vitamin C Cholesterol Omega-3 DNA Damage Fasting Coffee Magnesium Eyes Calcium Time-Restricted Eating Breast Milk Moringa LactateDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
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Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.
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Performance Brain Alzheimer's Cancer Gut Aging Ketosis Insulin Resistance Podcast Cholesterol Inflammation Immune System InsulinDr. Peter Attia discusses dietary strategies to promote longevity and optimal performance.
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Dr. Ronald Krauss discusses the role that LDL cholesterol plays in heart disease, dyslipidemia, and atherosclerosis.
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Obesity Nutrition Aging Heart Disease Insulin Resistance Cholesterol Inflammation Magnesium Vitamin K SeleniumDr. Bruce Ames discusses the CHORI Bar, a micronutrient- and fiber-dense nutrition bar developed in the Ames laboratory to manage obesity.
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Biomarkers Vitamin D Nutrition Exercise Alzheimer's Gut Microbiome Performance Insulin Resistance Podcast CholesterolJim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.
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Brain Nutrition Exercise Alzheimer's Cholesterol Omega-3 Inflammation Depression Probiotics DNA Damage Stem Cells Serotonin Mental Health Cannabinoid CurcuminDr. Rhonda Patrick makes her third appearance on the Joe Rogan Experience.
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Nutrition Brain Diet Epigenetics Cholesterol Omega-3 Inflammation Micronutrients Multiple Sclerosis Mitochondria Vitamin K Antioxidant AutoimmunityDr. Terry Wahls discusses the nutrition protocol she used to reverse her secondary-progressive multiple sclerosis.
Topic Pages
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Carotenoids
Carotenoids and cholesterol co-absorb via mixed micelles, share NPC1L1 and SR-B1 transporters, and carotenoids modulate hepatic cholesterol metabolism.
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Cold exposure
Cold exposure activates adrenergic brown adipose thermogenesis, enhancing LDL receptor–mediated hepatic clearance and biliary cholesterol excretion.
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Sugar-sweetened beverages (SSBs)
Fructose-laden SSBs accelerate hepatic de novo lipogenesis, boosting VLDL secretion, raising LDL cholesterol and lowering HDL levels.
News & Publications
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Eggs are a dietary paradox: high in cholesterol but rich in brain-boosting nutrients, including choline, lutein, and zeaxanthin. While some studies indicate that eggs maintain cognitive health, others report the converse. A recent study found that eating eggs may help women preserve semantic memory—crucial for language comprehension and factual recall—as they age.
Researchers analyzed data from 890 adults aged 55 and older. Participants reported their egg consumption using a food frequency questionnaire, and researchers measured their memory and thinking skills at two clinic visits about four years apart.
They found that women who ate five eggs weekly experienced less decline in verbal fluency, a measure of semantic memory, than those who ate fewer eggs. In men, researchers found no clear relationship between egg intake and changes in cognitive performance. Eating eggs did not appear to harm cognitive function in either sex.
These findings suggest that eggs play a small but beneficial role in preserving memory in women. They also align with other research demonstrating that people with moderate choline intake—roughly the amount in two eggs—are about half as likely to have low cognitive function than those with the lowest intake.
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What are the optimal time-restricted eating patterns for cardiovascular wellness? pubmed.ncbi.nlm.nih.gov
Time-restricted eating is a dietary pattern that restricts the time during which a person eats to a specific window, such as a “16:8" pattern, where they fast for 16 hours a day and consume food only during the remaining eight hours. Evidence suggests that time-restricted eating improves cognitive function, supports weight loss, and reduces systemic inflammation. Findings from a recent review and meta-analysis suggest that time-restricted eating also reduces the risk of cardiovascular disease.
Researchers analyzed the findings of 33 studies involving 1,725 participants investigating the effects of time-restricted eating on markers of cardiovascular health. They conducted a sub-group analysis to determine how age, health characteristics, and eating patterns influenced the effects of time-restricted eating.
They found that the effects of time-restricted eating on cardiovascular disease varied according to a person’s risk factors, age, and when they ate. The table below presents their findings for the optimal time-restricted eating for different groups.
This meta-analysis and review identifies the optimal time-restricted eating interventions for blood pressure, obesity, lipids, and glucose. It effectively provides a best-practices guide for people interested in implementing time-restricted eating as a lifestyle modification to improve cardiovascular health. Learn more about time-restricted eating in this episode featuring Dr. Satchin Panda.
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Hypertensive smoking women have up to 20-fold higher risk of brain aneurysm ruptures. (2013) www.sciencedaily.com
From the article:
- If smoking women with high systolic blood pressure values have 20 times higher rate of these brain bleeds than never-smoking men with low blood pressure values, it may very well be that these women diagnosed with unruptured intracranial aneurysms should be treated. On the other hand, never-smoking men with low blood pressure values and intracranial aneurysms may not need to be treated at all.
In this largest SAH risk factor study ever, the study group also identified three new risk factors for SAH: previous myocardial infarction, history of stroke in mother, and elevated cholesterol levels in men. The results revise the understanding of the epidemiology of SAH and indicate that the risk factors for SAH appear to be similar to those for other cardiovascular diseases.
- We have previously shown that lifestyle risk factors affect significantly the life expectancy of SAH survivors, and now we have shown that the same risk factors also affect dramatically the risk of SAH itself.
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Smokers may be nearly twice as likely to develop an abdominal aortic aneurysm. (2016) www.eurekalert.org
From the article:
The study found the lifetime risk of an abdominal aortic aneurysm were: 1 in 17 among all study participants; 1 in 9 among current smokers; 1 in 9 among those in the top third of smoking pack-years (number of cigarettes smoked over a lifetime), whether a current or former smoker; 1 in 12 among current female smokers.
Researchers also found those who had quit smoking for 3-8 years (recent quitters) still had an approximately 2.6 to 3.5 fold increased risk for both clinical and asymptomatic abdominal aortic aneurysm in the next 15 years compared to never smokers. Their lifetime risk was 6.6 percent higher than long-term quitters.
For women, authors note the steep increase in risk is particularly concerning given the United States Preventive Services Task Force recommends that current or former male smokers undergo an ultrasound screening for an abdominal aortic aneurysm once between the ages of 65 and 75 but makes no such recommendation for women.
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The study also found that being older, white, or having high levels of bad cholesterol also increased the risk of abdominal aortic aneurysm.
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Red wine mitigates the negative neurological effects of high LDL cholesterol even without reducing its levels directly. www.tandfonline.com
Since the 1980’s, clinicians and researchers have been puzzled by the “French paradox”: the observation that residents of France have a surprisingly low incidence of cardiovascular disease given their high rates of smoking, intakes of saturated fat, and hypercholesterolemia (i.e. abnormally high serum levels of harmful low-density lipoprotein (LDL) cholesterol). A recent study now offers evidence that the negative health impacts of these common risk factors might be effectively mitigated by the French habit of regular red wine consumption.
The authors of this study examined mice that had been genetically modified to lack LDL receptors – proteins crucial for removing LDLs from the bloodstream and initiating their degradation. This genetic modification, known as a “knock-out”, meant that the mice experienced a virtually life-long state of hypercholesterolemia, which served as the biological backdrop for an experiment on the potential health effects of wine consumption.
At the age of three months (early mouse adulthood), animals were randomly assigned to receive 60 days of unlimited access to either plain tap water or red wine diluted to yield a 6% ethanol solution. This concentration ensured that the animals consumed the human equivalent of a 5-ounce glass of wine on a daily basis.
When the researchers tested the mice on a variety of cognitive tasks, they discovered that the water-only group displayed learning and memory impairments characteristic of their poor lipid profiles. Their performance was particularly poor on a short-term memory test, where the animals turned out to be unable to recognize objects they had seen only an hour prior. Long-term memory retention was also compromised. In a test that required the animals to remember the location of an escape platform hidden in a tub of opaque water, the mice swam in the right direction only 20 percent of the time.
Interestingly, wine-consuming mice were not impaired to the same degree. And while their plasma lipid profiles were no better compared to their water-drinking peers, they had substantially lower levels of several biomarkers of neuroinflammation, such as GFAP and lectin. The findings indicate that red wine compounds might help protect against the negative health outcomes of hypercholesterolemia by interfering with the associated inflammatory processes.