Related Episodes for Roland Griffiths, Ph.D. on Psilocybin, Psychedelic Therapies & Mystical Experiences

“In this clip, Dr. Dominic D'Agostino explains the interrelationship between ketones and lactate as sources of energy for the brain and the role ketones may have in reducing oxidative stress through greater energetic efficiency.”

“- Practical details like temperature and duration of sauna use, the difference between a dry, wet and infrared sauna, sauna timing, as well as other forms of heat stress such as steam showers, hot baths, and hot yoga.”

“I am simply choosing not to blend them into my blueberry smoothie when the goal is to maximize polyphenol exposure.".(https://www.foundmyfitness.com/episodes/blueberry-solocast)'] A 2023 banana-smoothie study caught Rhonda's attention because the effect was unusually large and the mechanism made biological sense.”

“Small trials in older adults and people with mild cognitive concerns have reported improvements in selected memory, processing-speed, or task-switching measures, although the response varies by study, product, population, and outcome.”

“Dr. D'Agostino cautions against confusing a Westernized obesogenic high-fat diet with a ketogenic diet. In a well-designed preclinical study, researchers fed mice a cyclic ketogenic diet starting at midlife and observed improved healthspan, cognition, and brain function.”

“Dr. Patrick begins with a prospective Finnish cohort in which men reporting four to seven sauna sessions per week had lower dementia and Alzheimer's disease incidence than men reporting one session. The study is observational, male-only, and cannot prove that sauna caused the lower risk.”

“Drinking two to three cups per day is linked to roughly a 60% reduced risk of developing diabetes, a statistic that highlights coffee's robust metabolic benefits that arise from its ability to activate AMP-activated protein kinase (AMPK), a critical regulator of cellular energy metabolism.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”