Related Episodes for Why "second generation" epigenetic clocks are better at detecting biological age | Dr. Morgan Levine

“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”

“Large treadmill cohorts associate higher measured fitness with lower mortality, while a 46-year study of middle-aged men linked the highest fitness category with about 4.9 additional estimated life-years compared with the lowest category.”

“The 10,000-step target began as a memorable way to market a Japanese pedometer, not as a biological threshold. Walking still matters because replacing sedentary time with movement supports health, and large cohort studies associate more daily steps with lower mortality.”

“Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial - In sedentary middle-aged adults, 2 years of regular exercise improved heart function and reduced heart stiffness, potentially lowering future heart failure risk.”

“In the five-year Generation 100 trial, adults ages 70 to 77 completed supervised high-intensity interval training or moderate continuous training, demonstrating that structured vigorous exercise can be feasible in older populations when it is introduced progressively and matched to health and fitness.”

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“In this talk, we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.”

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”

Many of the anabolic effects of growth hormone are thought to be mediated by insulin-like growth factor-1, or IGF-1 (https://www.ncbi.nlm.nih.gov/pubmed/18500379), which is synthesized primarily in the liver but also in skeletal muscle in response to growth hormone.