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“Elevated biomarkers of inflammation, which are commonly observed in people who have depression, chronically activate the body's inflammatory response system, promoting the development of depressive symptoms and inducing changes in brain and neuroendocrine function.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“Scientists have also identified interesting links between depression and obesity – likely mediated by elevated inflammation, since fat cells produce a wide array of inflammatory factors. In this Aliquot segment, psychiatrist Dr. Charles Raison describes the links between inflammation and depression.”

“Observational studies using DXA or CT imaging associate higher alcohol intake with greater visceral fat, with individual responses shaped by dose, drinking pattern, diet, sex, activity, body composition, and metabolic health.”

“And, although these products are widely available on the common market in supplement form, Dr. Sinclair does not endorse them, preferring to focus his efforts on developing pharmaceutical-grade products. In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.”

“In this Aliquot, cardiologist Ben Levine, nutritional scientist and champion powerlifter Layne Norton, and I discuss the importance of recovery, how best to approach it, and some surprising, often overlooked aspects of this important part of fitness.”

“But the effects of liquid sugar extend to longevity, as well. In fact, consumption of sugar-sweetened beverages is associated with dramatically accelerated telomere shortening – equivalent to as much as five years of a person's life.”

“Dr. Patrick's practical answer is to use black coffee, a small amount of cream or MCT, or an unsweetened plant milk when frequent additions worsen the lipid tradeoff, and to assess ApoB rather than assume an additive is harmless.”

“In the prospective Framingham Offspring Study, people in the highest red-blood-cell DHA group had approximately 49 percent lower risk of developing Alzheimer's disease than those in the lowest group.”

“Dr. Patrick uses skin thickness as a simple buying framework: thin-skinned produce such as strawberries and apples receives more priority for organic purchasing than avocados, bananas, or oranges with peels that are removed.”