Search results for blood-brain barrier

“Microbleeds are markers of cerebral small vessel disease—age-related blood vessel impairments in the brain. These impairments compromise the blood-brain barrier, contributing to the development of cardiovascular disease, dementia, and stroke.”

“Over the long term, these changes can damage blood vessels and reduce blood flow to the brain. Other processes, such as inflammation and weakening of the blood-brain barrier (the system that controls what enters the brain) may also play a role.”

“Exercise supports the health of pericytes, tiny contractile cells surrounding the brain's capillaries that regulate vascular blood flow and maintain blood-brain barrier integrity. Pericytes detach from the blood vessels in aging, driving the pathophysiology of neurological dysfunction, vascular dementia, and mood disorders like anxiety.”

“The blood-brain barrier is a critical player in brain connectivity, and its impairment during aging contributes to cognitive dysfunction. Learn more in this episode featuring Dr. Axel Montagne.”

“These molecules can cross the blood-brain barrier and the placenta, potentially disrupting fetal neurodevelopment and impairing sensory processing abilities later in life. These impairments are often manifested in neuropsychiatric disorders such as autism or schizophrenia.”

“One possible player is interleukin-6 (IL-6), a cytokine that can cross the blood-brain barrier, increasing the barrier's permeability and promoting brain inflammation. In turn, this inflammation can impair synaptic pruning, a natural process that occurs in the brain between early childhood and adulthood and eliminates extra synapses.”

“Maternal immune activation due to autoimmune disorders, asthma, or allergies switches on the activity of inflammatory pathways and proinflammatory molecules. Many of these molecules can cross the blood–brain barrier and the placenta, potentially disrupting fetal development.”

“Most of the body's glycogen stores are found in the muscles and liver, but some glycogen is found in the brain, primarily in the astrocytes, a type of cell involved in neurogenesis and blood-brain barrier maintenance.”

“The mice that ate the ketogenic diet lost less weight, maintained better blood oxygen levels, and had improved survival rates compared to the mice that ate the regular chow. In addition, the mice on the ketogenic diet had higher levels of specialized T-cells in their lungs that enhanced airway cell mucus production to improve lung barrier function.”

“Ketone bodies can cross the blood-brain barrier to enter the brain and neuronal mitochondria, where they provide essential energy. Dr. Mattson describes an added bonus of ketones: They burn "cleaner" than glucose, yielding fewer free radicals during their metabolism.”