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Science Digest

Small-vessel disease could provoke amyloid pathology while Alzheimer's-associated cerebral amyloid pathology may lead to auxiliary vascular damage

May 4, 2022

“A variant in the APOE gene, called apolipoprotein E4 (APOE4), is the major genetic risk factor for Alzheimer's disease. Having one APOE4 allele increases a person's Alzheimer's disease risk as much as threefold; carrying two APOE4 alleles increases risk as much as 15-fold.”

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