What is the "master clock" or Suprachiasmatic Nucleus? | Satchin Panda
The body's circadian system is composed of multiple "clocks" that are present in all cells. These clocks orchestrate the regulation of gene expression that coordinates essential metabolic processes. The body's master clock is located in the suprachiasmatic nucleus, or SCN, a tiny region of the brain located within the hypothalamus. The SCN, in turn, coordinates the body's peripheral clocks, such as those found in the liver, pancreas, muscles, and fatty tissue, driving rhythms of rest and activity that determine eating-fasting cycles. Damage to the SCN, such as would occur in Alzheimer's disease or other neurodegenerative processes, can dysregulate the body's normal responses to light, darkness, and food intake. In this clip, Dr. Satchin Panda explains the role of the suprachiasmatic nucleus – the body's master clock – and how it affects metabolism.
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