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“In order to study the effects of irisin supplementation, the investigators conducted a second experiment in which they administered exogenous (i.e., made outside the body) irisin to a strain of mice who develop an Alzherimer’s-like dementia at an early age due to loss of FNDC5 function.”

“After taking into account other factors, including age, race/ethnicity, poverty/income, tobacco and alcohol consumption, and physical activity, the authors also found that participants with overweight and obesity were nearly four times more likely to have low serum testosterone compared to lean males, independent of SSB consumption.”

“However, a study involving more than 2,500 mentally healthy older adults found that a higher daily dietary magnesium intake (at least 407 milligrams) was linked to better overall brain function, primarily among non-Hispanic white females with adequate vitamin D status, underscoring the interdependence of the two nutrients.”

“The microbiome of participants with Alzheimer's disease differed from those without Alzheimer's disease at the phylum, order, and family levels (i.e., scientific categories used to organize microbes into groups using their genes), with higher levels of phyla Bacteroidetes and lower levels of the phyla Actinobacteria and Verrucomicrobia and family Ruminococcaceae.”

“The disease is caused by a single genetic mutation, called a CAG repeat, that drives abnormal protein folding and aggregation of the huntingtin protein and subsequent death of striatal neurons.”

“Interestingly, repeated exposure to whole-body heat treatment through sauna use has an even more profound effect on boosting growth hormone immediately afterward: Seventeen men and women who were exposed to two one-hour sauna sessions at 80°C (176°F) dry heat (typical Finnish-style sauna) per day for seven days exhibited a 16-fold increase in growth hormone levels by the third day.”

Intravenous Vitamin C for the treatment of sepsis Sepsis, a life-threatening condition that can arise due to the body's response to a bacterial or viral infection, can cause severe injury to multiple tissues or organs.(Source: CDC) (https://www.cdc.gov/sepsis/index.html) People diagnosed with sepsis typically have low vitamin C levels, which might be predictive of increased risk for organ failure.

“The analysis pooled data from 23 studies comprising 606 participants and determined the mean difference of neuromuscular performance (jump performance and sprint times), subjective measures of fatigue, muscle soreness, and biochemical markers, following either cold water immersion or passive recovery performed no less than 24-hours post-exercise stressor.”

“While aerobic exercise is often viewed preferentially through the lens of cardiovascular health, the diverse cascade of biological effects from exercise as a whole — and aerobic exercise, in particular — culminate to make it one of the most formidable and immediately practical real-world interventions for human aging and the brain.”