Search results for cancer prevention

“Sulforaphane targets certain tissues, such as the prostate, breast, and bladder, where it exerts pharmacological effects that provide protection against cancer. In particular, sulforaphane promotes the activity of Nrf2, a transcription factor that regulates the expression of more than 200 cytoprotective enzymes.”

“In a 12-week randomized crossover trial, a modified ketogenic diet produced sustained physiological ketosis and improved daily function and quality of life compared with a usual diet supplemented with low-fat healthy-eating guidance.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Nicotinamide, NR, NMN, oral NAD, and intravenous NAD are related but not interchangeable. Nicotinamide has separate evidence in selected high-risk skin-cancer populations, summarized in a systematic review, while NR has the more developed oral human pharmacokinetic literature discussed here.”

“The conversion of glucosinolates to their cognate isothiocyanates via myrosinase-driven hydrolysis is not a direct path; rather, it occurs in a stepwise fashion, yielding a variety of intermediate bioactive compounds that can rearrange to form the final product.”

“Dr. D'Agostino cautions against confusing a Westernized obesogenic high-fat diet with a ketogenic diet. In a well-designed preclinical study, researchers fed mice a cyclic ketogenic diet starting at midlife and observed improved healthspan, cognition, and brain function.”

“Dr. Attia and Dr. Patrick agree that avoiding low vitamin D status is the clearest goal. Large prospective analyses consistently find higher risk at low 25-hydroxyvitamin D concentrations, while the evidence becomes less certain once people reach sufficiency.”

“In a four-month randomized trial of 88 overweight, untrained middle-aged adults, daily doses of 500 or 1,000 milligrams improved some muscle and mitochondrial measures, while the primary outcome of peak power did not significantly improve.”

“A systematic review in older adults linked Mediterranean dietary patterns with lower inflammatory markers, while a meta-analysis of randomized trials found that vitamin D supplementation reduced acute respiratory infection risk overall, with the strongest protection among people who were very deficient and received regular doses.”

“00:42:27 - The effects of an anti-malarial known as chloroquine which has some cytotoxic effects in cancer cells, but is actually (surprisingly) an inhibitor of autophagy. 00:43:12 - Studies of the lysosomal disrupter and anti-malarial chloroquine in combination with chemotherapy in the treatment of cancer.”